Govt. College of Arts,Science & Commerce, Khandola, Marcela-Goa
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A Magia de Mário: The Magic of Mário
(Casa De Goa, 2026) de Noronha, Oscar
Mário de Miranda: The Genius Who Drew A World
(Living Media India Limited, 2026-05) de Noronha, Oscar
Impact of the Prevalence of Shiga Toxin-Producing E. coli (STEC) in Dairy Production on Consumer Health
(JPS Scientific Publications, 2026) D’Costa, Dilecta
Milk is regarded as a highly nutritious and complete food, but it also serves as an excellent medium for microbial growth, making it vulnerable to contamination by pathogenic microorganisms. Among these, Escherichia coli, particularly Shiga toxin-producing E. coli (STEC), represents a major public health concern associated with milk and dairy products. Although the commercialization and pasteurization of milk have significantly reduced milk borne infections, contamination can still occur at various stages of production, processing, and distribution. STEC strains produce potent cytotoxins known as Shiga toxins (Stx1 and Stx2), which are responsible for a range of human illnesses from mild diarrhoea to severe conditions such as haemorrhagic colitis and haemolytic uremic syndrome (HUS). Cattle are considered the primary reservoir of STEC, and contamination of raw milk and dairy products can occur through faecal shedding and poor hygienic practices during milking and handling. Numerous serotypes of STEC, including O157: H7 and non-O157 serogroups such as O26, O103, O111, O121 and O145, have been implicated in outbreaks worldwide. Detection of virulence genes such as stx1, stx2, eae, and ehxA using molecular techniques like PCR and real-time PCR
has improved the rapid identification and characterization of pathogenic strains. Advanced molecular subtyping methods including pulsed-field gel electrophoresis (PFGE), multilocus variable-number tandem repeat analysis (MLVA), and other genotyping tools are widely used for epidemiological investigations and outbreak tracking. Additionally, increasing reports of antibiotic-resistant STEC strains highlight the
need for continuous surveillance and responsible antimicrobial use in dairy farming.
Synthesis and Biological Evaluation of 5′-Deoxy-adenosine Derivatives as A3 Adenosine Receptor Ligands
(American Chemical Society, 2025) Kim, Minjae; Naik, Siddhi D.; Choi, Hongseok; Kim, Seung Woo; Park, Jung Hoon; Joung, Misuk; Song, Jiyoon; Gaikwad, Vidyasagar B.; Jeong, Lak Shin
The A3 Adenosine Receptor (A3AR) is an important therapeutic target due to its role in inflammation and immune response regulation. Herein, we synthesized and evaluated 5′-deoxy-adenosine derivatives with oxygen at the 4′-position, comparing them to previously studied 4′-thionucleosides. Compound 1h exhibited the highest binding affinity (Ki = 5.9 ± 1.1 nM), consistent with the trend observed in the 4′-thionucleosides. Notably, the 5′-deoxy-adenosine derivatives demonstrated enhanced agonistic activity. Docking studies with compound 1h revealed a shift in binding mode when oxygen replaced sulfur at the 4′-position. The compounds retained strong interactions with critical residues, such as Thr94, even without a hydrogen bond donor at the 5′-position. These results explain the increased agonistic effect observed when the ring heteroatom was changed from sulfur to oxygen.
Installing Jotform Al Chatbot Application on Weebly Library Website: A Practical Approach for Virtual Reference Services
(Narayan Zantye College of Commerce, Bicholim, Goa, 2026) Faras, Ajit; Gaude, Shushma
This paper presents a practical study on the installation and implementation of the Jotform Al Chatbot on a Weebly-based academic library website. It examines the role of Al chatbots in enhancing library reference services, describes the step-by-step installation process on the Weebly platform, and evaluates the advantages and limitations of using Jotform AI Chatbot for virtual reference support. The study finds that Jotform AI Chatbot is a cost-effective, easy-to-use, and efficient tool that enables academic libraries to strengthen their digital reference services without requiring advanced technical expertise.