Govt. College of Arts,Science & Commerce, Khandola, Marcela-Goa

Accredited by NAAC with Grade A+ (CGPA: 3.43)

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Synthesis and Biological Evaluation of 5′-Deoxy-adenosine Derivatives as A3 Adenosine Receptor Ligands
(American Chemical Society, 2025) Kim, Minjae; Naik, Siddhi D.; Choi, Hongseok; Kim, Seung Woo; Park, Jung Hoon; Joung, Misuk; Song, Jiyoon; Gaikwad, Vidyasagar B.; Jeong, Lak Shin
The A3 Adenosine Receptor (A3AR) is an important therapeutic target due to its role in inflammation and immune response regulation. Herein, we synthesized and evaluated 5′-deoxy-adenosine derivatives with oxygen at the 4′-position, comparing them to previously studied 4′-thionucleosides. Compound 1h exhibited the highest binding affinity (Ki = 5.9 ± 1.1 nM), consistent with the trend observed in the 4′-thionucleosides. Notably, the 5′-deoxy-adenosine derivatives demonstrated enhanced agonistic activity. Docking studies with compound 1h revealed a shift in binding mode when oxygen replaced sulfur at the 4′-position. The compounds retained strong interactions with critical residues, such as Thr94, even without a hydrogen bond donor at the 5′-position. These results explain the increased agonistic effect observed when the ring heteroatom was changed from sulfur to oxygen.
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Installing Jotform Al Chatbot Application on Weebly Library Website: A Practical Approach for Virtual Reference Services
(Narayan Zantye College of Commerce, Bicholim, Goa, 2026) Faras, Ajit; Gaude, Shushma
This paper presents a practical study on the installation and implementation of the Jotform Al Chatbot on a Weebly-based academic library website. It examines the role of Al chatbots in enhancing library reference services, describes the step-by-step installation process on the Weebly platform, and evaluates the advantages and limitations of using Jotform AI Chatbot for virtual reference support. The study finds that Jotform AI Chatbot is a cost-effective, easy-to-use, and efficient tool that enables academic libraries to strengthen their digital reference services without requiring advanced technical expertise.
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Evaluating the impact of financial and behavioural determinants on consumptive behaviour through the mediating role of mental accounting
(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Sukthankar, Sitaram; Fernandes, Relita; Gaonkar, Sadanand; Shetye, Arya
The role of mental accounting has emerged more clearly in the light of the contemporary changes in organisations and environments. Financial and behavioural determinants are increasingly recognised as key drivers of individual consumption patterns. The present study investigates the financial and behavioural factors that interact through mental accounting to shape consumptive behaviour among working individuals in Goa, India. The independent variables comprised financial factors, including digital wallet and financial literacy, and behavioural factors, such as overconfidence and time orientation, while consumptive behaviour was the dependent variable. This study is grounded in behavioural finance theory and employs a quantitative design, using survey data from 328 working individuals in Goa collected through a proportionate stratified random sampling method and analysed using partial least squares-structural equation modelling (PLS-SEM). Results show that digital wallets, financial literacy, and overconfidence significantly influence mental accounting, while overconfidence and mental accounting significantly affect consumptive behaviour; however, time orientation, digital wallets, and financial literacy show no significant direct effect on consumptive behaviour. Mental accounting does not mediate the relationship between digital wallets and consumptive behaviour, but fully mediates the relationship between financial literacy and consumptive behaviour.
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